Amyotrophic Lateral Sclerosis

(ALS; Lou Gehrig's Disease; Motor Neuron Disease)


Amyotrophic lateral sclerosis (ALS) is a progressive nervous system disorder. It gradually destroys the neurons responsible for muscle movement. Specifically, it affects the upper and lower motor neurons. Over time, ALS leads to almost total paralysis of muscle movement, including breathing. Eventually, the disorder leads to respiratory failure.
The Nervous System
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The cause of ALS is unknown. Genes may play a role.

Risk Factors

Factors that may increase your chance of ALS include:


Symptoms of ALS include:


You will be asked about your symptoms and medical history. A physical exam will be done. There are no tests that can definitively diagnose ALS. Tests may be used to rule out other medical conditions.
Imaging tests may include:
Other tests may include:
Your muscles and nerves may be evaluated. This can be done with electromyogram (EMG)/nerve conduction velocities (NCV).
Your cognitive skills may be assessed. This can be done with neuropsychological testing.


There is currently no cure for ALS.
Treatment may help to reduce or manage symptoms. A combination of treatments may work best. This may include:
Treatment options include:


The drug riluzole has been approved for ALS. The drug may slightly improve functioning, but it does not stop the disease from progressing.
Medications may include:
  • Muscle relaxants reduce spasticity
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) and other pain medications
  • Atropine, scopolamine, botulinum toxin, antihistamine to reduce heavy drooling
  • Antidepressants and anti-anxiety drugs
  • A combination of dextromethorphan and quinidine to treat inappropriate laughter or crying

Other Types of Treatments

Supportive care may be needed as ALS progresses, including:
  • Physical therapy—To reduce pain associated with muscle cramping and spasticity.
  • Respiratory care—In some cases, you may need to receive a mixture of air and oxygen from a machine. A device may also be used that helps your breathing muscles contract. If you cannot move enough air in and out of your lungs, you may need surgery to have a tube inserted into your airway.
  • Nutritional care—Your doctor may make changes to your diet. In some cases, getting nutrition through tube feeding is needed.
  • Speech therapy—Speech therapy may be used to optimize communication. Therapy may include exploring alternate methods of communication.


There are no current guidelines to prevent ALS because the cause is unknown.


ALS Association

National Institute of Neurological Disorders and Stroke


ALS Canada

Amyotrophic Lateral Sclerosis Society of British Columbia


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NeuRx Diaphragm Pacing System. Food and Drug Administration website. Available at: Updated September 6, 2013. Accessed February 12, 2016.

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4/17/2008 DynaMed Systematic Literature Surveillance Fornai F, Longone P, Cafaro L, et al. Lithium delays progression of amyotrophic lateral sclerosis. Proc Natl Acad Sci USA. 2008;105(6):2052-2057.

1/14/2011 DynaMed's Systematic Literature Surveillance Mateen FJ, Carone M, Sorenson EJ. Patients who survive 5 years or more with ALS in Olmsted County, 1925-2004. J Neurol Neurosurg Psychiatry. 2010;81(10):1144-1146.

9/3/2014 DynaMed's Systematic Literature Surveillance. Available at: Wippold FJ, Cornelius RS, Broderick DF, et al. American College of Radiology (ACR) Appropriateness Criteria for dementia and movement disorders. Available at: Updated 2014. Accessed February 12, 2016.

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